76. Grams RJ, Yuan K, Founds MW, Ware ML, Pilar MG, Hsu KL. Imidazoles are Tunable Nucleofuges for Developing Tyrosine-Reactive Electrophiles. ChemBioChem. 2024; 25(16): e202400382.
75. Hsu KL, Schumann B, Sletten E, Vinogradova E, Zou P. Voices: Challenges and opportunities for bioorthogonal chemistry. Cell Chem Bio. 2024; 31(3): 380-382.
74. Chen M, Shin M, Ware TB, Donvito G, Muchhala KH, Mischel R, Mustafa MA, Serbulea V, Upchurch CM, Leitinger N, Akbarali HI, Lichtman AH, and Hsu KL. Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling. PNAS. 2023; 120(52): e2304900120.
73. Heindel AJ, Brulet JW, Wang X, Founds MW, Libby AH, Bai DL, Lemke MC, Leace DM, Harris TE, Hafner M, and Hsu KL. Chemoproteomic capture of RNA binding activity in living cells. Nat Comm. 14, 6282 (2023).
72. Mendez R, Shaikh MS, Lemke MC, Yuan K, Libby AH, Bai DL, Ross MM, Harris TE, and Hsu KL. Predicting small molecule binding pockets on diacylglycerol kinases using chemoproteomics and AlphaFold. RSC Chem Biol. 4, 422-430 (2023).
71. Ciancone AM*, Seo KW*, Chen M*, Borne AL, Libby AH, Bai DL, Kleiner RE*, and Hsu KL*. Global discovery of covalent modulators of ribonucleoprotein granules. J Am Chem Soc. 145, 11056-11066 (2023).
70. Brulet JW*, Ciancone AM*, Yuan K*, and Hsu KL. Advances in activity-based protein profiling of functional tyrosines in proteomes. Isr J Chem. 2023; 63: e202300001.
69. Ciancone AM, Hosseinibarkooie S, Bai DL, Borne AL, and Hsu KL. Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022; 29: 1709-1720.
68. Grams RJ and Hsu KL. Catch your breath. Nat Chem Biol. 2022; 18: 686-687.
67. Ozturk H, Cingoz H, Tufan T, Yang J, Adair SJ, Tummala KS, Kuscu C, Kinali M, Comertpay G, Nagdas S, Goudreau BJ, Luleyap HU, Bingul Y, Ware TB, Hwang WL, Hsu KL, Kashatus DF, Ting DT, Chandel NS, Bardeesy N, Bauer TW, and Adli M. ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer. Dev Cell. 2022; 57: 1331-1346.
66. Grams RJ and Hsu KL. Reactive chemistry for covalent probe development and therapeutic discovery. Trends Pharmacol Sci. 2022; 43: 249-262.
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65. McCloud RL, Yuan K, Mahoney KE, Bai DL, Shabanowitz J, Ross MM, Hunt DF, and Hsu KL. Direct target site identification of a sulfonyl-triazole covalent kinase probe by LC-MS chemical proteomics. Anal Chem. 2021; 93: 11946-11955.
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64. Hussain SS, Tran T, Ware TB, Luse MA, Prevost CT, Ferguson AN, Kashatus JA, Hsu KL, and Kashatus DF. RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal. Cell Rep. 2021; 36: 109451.
63. Ware TB and Hsu KL. Advances in chemical proteomic evaluation of lipid kinases – DAG kinases as a case study. Curr Opin Chem Biol. 2021; 65: 101-108.
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62. Nass SR, Steele FF, Ware TB, Libby AH, Hsu KL, and Kinsey SG. Monoacylglycerol lipase inhibition using JZL184 attenuates paw inflammation and functional deficits in a mouse model of inflammatory arthritis. Cannabis Cannabinoid Res. 2021; 6: 233-241.
61. Cao JK, Viray K, Shin M, Hsu KL, Mackie K, Westenbroek R, and Stella N. ABHD6 inhibition rescues a sex-dependent deficit in motor coordination deficit in the HdhQ200/200 mouse model of Huntington’s disease. J Neurol Neurol Disord. 2021; 7: 1-16.
60. Toroitich EK, Ciancone AM, Hahm HS, Brodowski SM, Libby AH, and Hsu KL. Discovery of a cell-active SuTEx ligand of prostaglandin reductase 2. ChemBioChem. 2021; 22: 2134-2139.
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59. Hsu KL. Shining a light on phenotypic drug discovery. Cell Chem Biol. 2021; 28: 115-117.
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58. Huang T, Borne AL, Brulet JW, and Hsu KL. Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021; 12: 3295-3307.
57. Borne AL, Brulet JW, Yuan K, and Hsu KL. Development and biological applications of sulfur-triazole exchange (SuTEx) chemistry. RSC Chem Biol. 2021; 2: 322-337.
56. Georgiev GA, Gh MS, Romano J, Teixeira KLD, Struble C, Ryan D, Sia K, Kitt JP, Harris JM, Hsu KL, Libby AH, Odrich MG, Suarez T, McKown R, and Laurie GW. Lacritin proteoforms promote and restore stability of the tear lipid layer that then act as a natural slow release mechanism for epithelial homeostasis. J Biol Chem. 2021; 296: 100070.
55. Seki SM, Posyniak K, McCloud RL, Rosen DA, Fernandez-Castaneda A, Beiter RM, Hayes N, Spivey C, Gemta L, Bullock TNJ, Hsu KL, and Gaultier A. Modulation of PKM activity controls differentiation of Th17 cells. Sci Signal. 2020; 13: eaay9217
54. Brulet JW, Borne AL, Yuan K, Libby AH, and Hsu KL. Liganding functional tyrosine sites on proteins using sulfur-triazole exchange chemistry. J Am Chem Soc. 2020; 142: 8270-8280.
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53. Shin M, Ware TB, and Hsu KL. DAGL-beta functions as a PUFA-specific triacylglycerol lipase in macrophages. Cell Chem Biol. 2020; 27: 314-321.
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52. Ware TB, Franks CE, Granade ME, Zhang M, Kim KB, Park KS, Gahlmann A, Harris TE, and Hsu KL. Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering. Nat Chem Biol. 2020; 16: 170-178.
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51. Yin B, Mendez R, Zhao X, Rakhit R, Hsu KL, and Ewald S. Automated spatially targeted optical micro proteomics (autoSTOMP) to determine protein complexity of subcellular structures. Anal Chem. 2020; 92: 2005-2010.
50. Hahm HS*, Toroitich EK, Borne AL, Brulet JW, Libby AH, Yuan K, Ware TB, McCloud RL, Ciancone AM, and Hsu KL. Global targeting of functional tyrosines using sulfur triazole exchange chemistry. Nat Chem Biol. 2020; 16: 150-159.
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*recommended by:
 *highlighted by Synfacts
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49. Lazo JS, Blanco IK, Tasker NR, Rastelli EJ, Burnett JC, Garrott SR, Hart DJ, McCloud RL, Hsu KL, Wipf P, and Sharlow ER. Next-generation cell-active inhibitors of the undrugged oncogenic PTP4A3 phosphatase. J Pharmacol Exp Ther. 2019; 371: 652-662.
48. Franks CE and Hsu KL. Activity-Based Kinome Profiling using Chemical Proteomics and ATP Acyl Phosphates. Curr Protoc Chem Biol. 2019; 11: e72.
47. Ware TB, Shin M, and Hsu KL. Metabolomics analysis of lipid metabolizing enzyme activity. Methods Enzymol. 2019, 626: 407-428.
46. Shin M, Buckner A, Prince J, Bullock TNJ, and Hsu KL. Diacylglycerol lipase-beta is required for TNF-alpha response but not CD8+ T cell priming capacity of dendritic cells. Cell Chem Biol. 2019; 26: 1036-1041.
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45. Borne AL, Huang T, McCloud RL, Pachaiyappan B, Bullock TN, and Hsu KL. Deciphering T cell immunometabolism with activity-based protein profiling. Curr Top Microbiol Immunol. 2019; 420: 175-210.
44. Shin M, Ware TB, Lee HC, and Hsu KL. Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond. Biochim Biophys Acta. 2019; 1864: 907-921.
43. Campbell ST, Franks CE, Borne AL, Shin M, Zhang L, and Hsu KL. Chemoproteomic discovery of a ritanserin-targeted kinase network mediating apoptotic cell death of lung tumor cells. Mol Pharmacol. 2018; 94: 1246-1255.
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42. Manterola A, Bernal-Chico A, Cipriani R, Ruiz A, Perez-Samartin A, Moreno-Rodriguez M, Hsu KL, Cravatt BF, Brown JM, Rodriguez-Puertas R, Matute C, and Mato S. Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis. Neuropharmacology. 2018; 141: 181-191.
41. Manterola A, Bernal-Chico A, Cipriani R, Canedo-Antelo M, Moreno-Garcia A, Martin-Fontecha M,Perez-Cerda F, Sanchez-Gomez MV, Ortega-Gutierrez S, Brown M, Hsu KL, Cravatt BF, Matute C, and Mato S. Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination. Biochem Pharmacol. 2018; 157: 189-201.
40. Curry Z, Wilkerson J, Bagdas D, Kyte S, Patel N, Donvito G, Mustafa MA, Poklis J, Niphakis M, Hsu KL, Cravatt BF, Gewirtz DA, Damaj MI, and Lichtman AH. Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy. J Pharmacol Exp Ther. 2018; 366:169-83.
39. Wilkerson JL, Curry ZA, Kinlow PD, Mason BL, Hsu KL, van der Stelt M, Cravatt BF, and Lichtman AH. Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice. Pain 2018; 159: 1155-65.
38. Shin M, Franks CE, and Hsu KL. Isoform-selective activity-based profiling of ERK signaling. Chem Sci. 2018; 9:2419-31.
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*Featured in the cover
*Featured as a 2018 Chemical Science HOT Article
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37. McCloud RL, Franks CE, Campbell ST, Purow BW, Harris TE, and Hsu KL. Deconstructing lipid kinase inhibitors by chemical proteomics. Biochemistry 2018; 57:231-36.
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*highlighted in Future of Biochemistry special issue
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36. Shin M, Snyder HW, Donvito G, Schurman LD, Fox TE, Lichtman AH, Kester M, and Hsu KL. Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy In Vivo. Mol Pharm. 2018; 15: 721-28.
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*highlighted in Pharmacology by Chemical Biology special issue
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35. Franks CE, Campbell ST, Purow BW, Harris TE, and Hsu KL. The Ligand Binding Landscape of Diacylglycerol Kinases. Cell Chem Biol. 2017; 24: 870-80
*highlighted on the ASBMB Lipid Corner. Video here
*highlighted on the ASBMB Lipid Corner. Video here
34. Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. Biochem Biophys Res Commun. 2017; 490: 1226-31
33. Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu KL*, and Cravatt BF*. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem Biol. 2015; 10: 925
*co-corresponding authors
Graduate and Postdoctoral Work:
32. Wilkerson JL, Ghosh S, Bagdas D, Mason BL, Crowe MS, Hsu KL, Wise LE, Kinsey SG, Damaj MI, Cravatt BF, and Lichtman AH. Diacylglycerol lipase beta inhibition reverses nociceptive behavior in mouse models of inflammatory and neuropathic pain. Br J Pharmacol. 2016; 173: 1678-92.
31. Buczynski MW, Herman MA, Hsu KL, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ, Cravatt BF, Roberto M, Loren H Parsons LH. Diacylglycerol lipase disinhibits VTA DA neurons during chronic nicotine exposure. PNAS. 2016; 113: 1086-91.
30. Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, Den Dulk H, Allara M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, Overkleeft HS, Hankemeier T, Werkman TR, Cravatt BF, and van der Stelt M. A highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons. J Am Chem Soc. 2015; 137: 8851-57.
29. Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, and Nomura DK. Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer. ACS Chem Biol. 2015; 10:1624-30.
28. Manna JD, Wepy JA, Hsu KL, Chang JW, Cravatt BF, and Marnett LJ. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. J Biol Chem. 2014; 289: 33741-53.
27. Inloes J, Hsu KL, Dix MM, Viader A, Masuda K, Takei T, Wood MR, and Cravatt BF. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci. 2014; 111:14924-29.
26. Grim TW, Ghosh S, Hsu KL, Cravatt BF, Kinsey SG, Lichtman AH. Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models. Pharmacol Biochem Behav. 2014; 124:405-11. PubMed PMID: 25058512.
25. Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs WR, Blankman JL, Tu S, Cherry AE, Fung S, Wen A, Li W, Saporito MS, Selley DE, Cravatt BF, Oakley JC, Stella N. ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice. Neuron. 2014; 83:361-71. PubMed PMID: 25033180.
24. Agrawal P, Kurcon T, Pilobello KT, Rakus JF, Koppolu S, Liu Z, Batista BS, Eng WS, Hsu KL, Liang Y, Mahal LK. Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proc Natl Acad Sci. 2014; 111:4338-43. PubMed PMID: 24591635; PubMed Central PMCID: PMC3964104.
23. Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat Chem Biol. 2014; 10:113-21. PubMed PMID: 24362705; PubMed Central PMCID: PMC3953460.
22. Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem. 2014; 289:1491-504. PubMed PMID: 24297180; PubMed Central PMCID: PMC3894331.
21. Hsu KL*, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF*. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). J Med Chem. 2013; 56:8270-9. PubMed PMID: 24152295; PubMed Central PMCID: PMC3987869.
20. Hsu KL*, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF*. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. J Med Chem. 2013; 56:8257-69. PubMed PMID: 24152245; PubMed Central PMCID: PMC3984011.
19. Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorg Med Chem Lett. 2013; 23:839-43. PubMed PMID: 23260346; PubMed Central PMCID: PMC3549684.
18. Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol. 2012; 8:999-1007. PubMed PMID: 23103940; PubMed Central PMCID: PMC3513945.
17. Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. J Am Chem Soc. 2012; 134:10345-8. PubMed PMID: 22690931; PubMed Central PMCID: PMC3392194.
16. Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, López-Alberca MP, Fu GC, Cravatt BF. Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition. J Am Chem Soc. 2012; 134:5068-71. PubMed PMID: 22400490; PubMed Central PMCID: PMC3326416.
15. Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol. 2011; 7:469-78. PubMed PMID: 21572424; PubMed Central PMCID: PMC3118922.
14. Propheter DC, Hsu KL, Mahal LK. Recombinant lectin microarrays for glycomic analysis. Methods Mol Biol. 2011; 723:67-77. PubMed PMID: 21370060.
13. Hsu KL, Pilobello K, Krishnamoorthy L, Mahal LK. Ratiometric lectin microarray analysis of the mammalian cell surface glycome. Methods Mol Biol. 2011; 671:117-31. PubMed PMID: 20967626.
12. Propheter DC, Hsu KL, Mahal LK. Fabrication of an oriented lectin microarray. Chembiochem. 2010; 11:1203-7. PubMed PMID: 20486145.
11. Hsu KL, Mahal LK. Sweet tasting chips: microarray-based analysis of glycans. Curr Opin Chem Biol. 2009; 13:427-32. PubMed PMID: 19716334.
10. Hsu KL, Gildersleeve JC, Mahal LK. A simple strategy for the creation of a recombinant lectin microarray. Mol Biosyst. 2008; 4:654-62. PubMed PMID: 18493664.
9. Hsu KL, Mahal LK. A lectin microarray approach for the rapid analysis of bacterial glycans. Nat Protoc. 2006; 1:543-9. PubMed PMID: 17406280.
8. Hsu KL, Pilobello KT, Mahal LK. Analyzing the dynamic bacterial glycome with a lectin microarray approach. Nat Chem Biol. 2006; 2:153-7. PubMed PMID: 16462751.
33. Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu KL*, and Cravatt BF*. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem Biol. 2015; 10: 925
*co-corresponding authors
Graduate and Postdoctoral Work:
32. Wilkerson JL, Ghosh S, Bagdas D, Mason BL, Crowe MS, Hsu KL, Wise LE, Kinsey SG, Damaj MI, Cravatt BF, and Lichtman AH. Diacylglycerol lipase beta inhibition reverses nociceptive behavior in mouse models of inflammatory and neuropathic pain. Br J Pharmacol. 2016; 173: 1678-92.
31. Buczynski MW, Herman MA, Hsu KL, Natividad LA, Irimia C, Polis IY, Pugh H, Chang JW, Niphakis MJ, Cravatt BF, Roberto M, Loren H Parsons LH. Diacylglycerol lipase disinhibits VTA DA neurons during chronic nicotine exposure. PNAS. 2016; 113: 1086-91.
30. Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, Den Dulk H, Allara M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, Overkleeft HS, Hankemeier T, Werkman TR, Cravatt BF, and van der Stelt M. A highly selective, reversible inhibitor identified by comparative chemoproteomics modulates diacylglycerol lipase activity in neurons. J Am Chem Soc. 2015; 137: 8851-57.
29. Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, and Nomura DK. Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer. ACS Chem Biol. 2015; 10:1624-30.
28. Manna JD, Wepy JA, Hsu KL, Chang JW, Cravatt BF, and Marnett LJ. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. J Biol Chem. 2014; 289: 33741-53.
27. Inloes J, Hsu KL, Dix MM, Viader A, Masuda K, Takei T, Wood MR, and Cravatt BF. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci. 2014; 111:14924-29.
26. Grim TW, Ghosh S, Hsu KL, Cravatt BF, Kinsey SG, Lichtman AH. Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models. Pharmacol Biochem Behav. 2014; 124:405-11. PubMed PMID: 25058512.
25. Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs WR, Blankman JL, Tu S, Cherry AE, Fung S, Wen A, Li W, Saporito MS, Selley DE, Cravatt BF, Oakley JC, Stella N. ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice. Neuron. 2014; 83:361-71. PubMed PMID: 25033180.
24. Agrawal P, Kurcon T, Pilobello KT, Rakus JF, Koppolu S, Liu Z, Batista BS, Eng WS, Hsu KL, Liang Y, Mahal LK. Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proc Natl Acad Sci. 2014; 111:4338-43. PubMed PMID: 24591635; PubMed Central PMCID: PMC3964104.
23. Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat Chem Biol. 2014; 10:113-21. PubMed PMID: 24362705; PubMed Central PMCID: PMC3953460.
22. Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem. 2014; 289:1491-504. PubMed PMID: 24297180; PubMed Central PMCID: PMC3894331.
21. Hsu KL*, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF*. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). J Med Chem. 2013; 56:8270-9. PubMed PMID: 24152295; PubMed Central PMCID: PMC3987869.
20. Hsu KL*, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF*. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. J Med Chem. 2013; 56:8257-69. PubMed PMID: 24152245; PubMed Central PMCID: PMC3984011.
19. Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorg Med Chem Lett. 2013; 23:839-43. PubMed PMID: 23260346; PubMed Central PMCID: PMC3549684.
18. Hsu KL, Tsuboi K, Adibekian A, Pugh H, Masuda K, Cravatt BF. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol. 2012; 8:999-1007. PubMed PMID: 23103940; PubMed Central PMCID: PMC3513945.
17. Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. J Am Chem Soc. 2012; 134:10345-8. PubMed PMID: 22690931; PubMed Central PMCID: PMC3392194.
16. Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, López-Alberca MP, Fu GC, Cravatt BF. Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition. J Am Chem Soc. 2012; 134:5068-71. PubMed PMID: 22400490; PubMed Central PMCID: PMC3326416.
15. Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol. 2011; 7:469-78. PubMed PMID: 21572424; PubMed Central PMCID: PMC3118922.
14. Propheter DC, Hsu KL, Mahal LK. Recombinant lectin microarrays for glycomic analysis. Methods Mol Biol. 2011; 723:67-77. PubMed PMID: 21370060.
13. Hsu KL, Pilobello K, Krishnamoorthy L, Mahal LK. Ratiometric lectin microarray analysis of the mammalian cell surface glycome. Methods Mol Biol. 2011; 671:117-31. PubMed PMID: 20967626.
12. Propheter DC, Hsu KL, Mahal LK. Fabrication of an oriented lectin microarray. Chembiochem. 2010; 11:1203-7. PubMed PMID: 20486145.
11. Hsu KL, Mahal LK. Sweet tasting chips: microarray-based analysis of glycans. Curr Opin Chem Biol. 2009; 13:427-32. PubMed PMID: 19716334.
10. Hsu KL, Gildersleeve JC, Mahal LK. A simple strategy for the creation of a recombinant lectin microarray. Mol Biosyst. 2008; 4:654-62. PubMed PMID: 18493664.
9. Hsu KL, Mahal LK. A lectin microarray approach for the rapid analysis of bacterial glycans. Nat Protoc. 2006; 1:543-9. PubMed PMID: 17406280.
8. Hsu KL, Pilobello KT, Mahal LK. Analyzing the dynamic bacterial glycome with a lectin microarray approach. Nat Chem Biol. 2006; 2:153-7. PubMed PMID: 16462751.
BOOKS & CHAPTERS
7. Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). 2013 Apr 08 [updated 2014 Jan 13]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 24624468.
6. Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1). 2013 Apr 08 [updated 2014 Jan 13]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 24624465.
5. Hsu KL, Tsuboi K, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6). 2012 Apr 12 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23762934.
4. Adibekian A, Hsu KL, Speers AE, Monillas ES, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Bahnson BJ, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2). 2011 Mar 31 [updated 2013 Mar 07]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23658960.
3. Adibekian A, Hsu KL, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211. 2011 Mar 31 [updated 2013 Mar 07]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23658953.
2. Nagano JMG, Hsu KL, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Bahnson BJ, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH). 2011 Nov 30 [updated 2014 May 13]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23658952.
1. Hsu KL, Tsuboi K, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-β). 2012 Apr 16 [updated 2013 Feb 25]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23658950.
7. Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). 2013 Apr 08 [updated 2014 Jan 13]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 24624468.
6. Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1). 2013 Apr 08 [updated 2014 Jan 13]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 24624465.
5. Hsu KL, Tsuboi K, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6). 2012 Apr 12 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23762934.
4. Adibekian A, Hsu KL, Speers AE, Monillas ES, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Bahnson BJ, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2). 2011 Mar 31 [updated 2013 Mar 07]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23658960.
3. Adibekian A, Hsu KL, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211. 2011 Mar 31 [updated 2013 Mar 07]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23658953.
2. Nagano JMG, Hsu KL, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Bahnson BJ, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH). 2011 Nov 30 [updated 2014 May 13]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23658952.
1. Hsu KL, Tsuboi K, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H. Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-β). 2012 Apr 16 [updated 2013 Feb 25]. Probe Reports from the NIH Molecular Libraries Program. PubMed PMID: 23658950.